Breast cancer risk assessment in Iranian women by Gail model

  Abstract   Background: Due to the high incidence of breast cancer and the effect of its early   diagnosis on decreasing morbidity and mortality, we used the Gail model to study   breast cancer risk in Iranian women.   Methods: This study was done in a simple randomized way. Participants were 2000   Iranian women older than 35 years old. The questionnaire consisted of demographic   data such as age, race (optional ) marriage status , level of education and standard questions of the Gail model. Gathered data were given in http://bcra. nci. nih.gov/brc. The breast cancer risk was calculated within the next 5 years and within the 90 years life   span. The statistical analysis was done by SPSS software.   Results: Mean age of women in the study was 47.95 years .50% of women had their   menarche at/older than fourteen years of age. 50% of women had first childbirth in   their twenties. 87% had a negative family history of breast cancer. 94% had no history   of breast biopsy. Of the remaining 6%, no tissue atypia was reported. In the present   study, breast cancer risk within 5 years was 0.92% and the breast cancer risk within 90   years of life was 9.14%. 7% showed risk of more than 1.67% in the Gail model. The   age ranged between 55-65 years in this high risk group.   Conclusion: In our study of breast cancer risk in Iranian women, breast cancer risk   was lower than the control group in the Gail model estimate for 5 years and a 90-year   life span. (0.92% versus 1.02% , 9.14% versus 11.21%). The differences were statistically significant (p<0.001).